Discontinue use if hearing or vestibular dysfunction is noted during course of treatment.After verifying that the eardrum is intact, shake well and instill drops twice daily into the ear canal. Clip excessive hair from treatment area.Before instilling medication into ear, examine external ear canal thoroughly to be certain the tympanic membrane is not ruptured to avoid possibility of transmitting infection to the middle ear as well as damaging the cochlea or vestibular apparatus from prolonged contact. Remove foreign material, debris, crusted exudates etc.
Thoroughly clean and dry external ear before treatment. Unused product should be returned to a veterinarian. Wash hands after use.Disposal Dispose of empty container by wrapping with paper and putting in garbage. If product in eye, wash out immediately with water. Other congenital anomalies including deformed forelegs, phocomelia, and anasarca have been reported in offspring of dogs which received corticosteroids during pregnancy.Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, foetal death, retained placenta and metritis.Administration of recommended doses of Otomax beyond seven days may result in delayed wound healing.Use restricted to situations where sensitivity testing indicates no other alternative antibiotic.Will irritate eyes. Identification of infecting organisms should be made either by microscopic roll smear evaluation or by culture as appropriate.If overgrowth of nonsusceptible bacteria, fungi or yeasts occur, or if hypersensitivity develops, treatment should be discontinued and appropriate therapy instituted.Corticosteroids administered to dogs, rabbits and rodents during pregnancy have resulted in cleft palate offspring. Betamethasone, an analogue of prednisolone, has a high degree of corticosteroid activity and a slight degree of mineralocorticosteroid activity.Pharmacokinetics Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Pharmacology Betamethasone valerate is a synthetic adrenocorticoid for dermatological use. Specifically, gentamicin is active against the following organisms commonly isolated from canine ears: Staphylococcus intermedius, other coagulase positive Staphylococcus sp., Pseudomonas aeruginosa, Proteus sp., and Escherichia coli. In vitro tests have determined that gentamicin is bactericidal and acts by inhibiting normal protein synthesis in susceptible microorganisms. Inflammation can increase percutaneous absorption.Microbiology Gentamicin sulfate is an aminoglycoside antibiotic active against a wide variety of pathogenic Gram-negative and Gram-positive bacteria. Topical corticosteroids can be absorbed from normal, intact skin. Clotrimazole is very poorly absorbed following dermal application.Betamethasone valerate, the 17-valerate ester of betamethasone, has been shown to provide anti-inflammatory and antipruritic activity in the topical management of corticosteroid responsive otitis externa.
These events began rapidly and extensively after addition of the drug. In studies of the mechanism of action, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorus compounds into the ambient medium with concomitant breakdown of cellular nucleic acids and accelerated potassium efflux. mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida sp., and Malassezia pachydermatis (formerly Pityrosporum canis ).Resistance to clotrimazole is very rare among the fungi that cause superficial mycoses. In vitro, clotrimazole exhibits fungistatic and fungicidal activity against isolates of Trichophyton rubrum, T. The primary action of clotrimazole is against dividing and growing organisms. Administration to food producing animals or to pregnant or lactating animals.Ĭlotrimazole is a broad spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes and yeasts. Concomitant use of drugs known to induce ototoxicity should be avoided. pachydermatis) and/or bacteria susceptible to gentamicin.Īdministration to dogs with known perforation of the eardrum (tympanic membrane). Treatment of canine acute and chronic otitis externa associated with yeast (M. gentamicin base 3409 IU/ml,īetamethasone valerate equiv.
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